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Closeup of Chicken Florentine Casserole being scooped from the baking dish.

Chicken Florentine Casserole (Low-Carb)

Craving a cozy, comforting dinner that’s ready in just 30 minutes? This Chicken Florentine Casserole is here to deliver! Creamy, cheesy, and packed with tender chicken, fresh spinach, and sun-dried tomatoes, it’s a low-carb twist on a classic comfort food favorite.
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Prep Time 10 minutes
Cook Time 30 minutes
Total Time 40 minutes
Course Main Course
Cuisine American, Italian
Servings 6
Calories 705 kcal

Ingredients
  

  • 1 pound low-carb penne pasta use regular penne if not low-carb
  • 10 ounces fresh baby spinach
  • 4 tablespoons olive oil divided
  • 1 pound chicken breasts cut into bite-sized pieces
  • 4 garlic cloves minced
  • 1/2 teaspoon xanthan gum use 2 tablespoons flour if not low-carb
  • 1/2 cup dry white wine See Notes
  • 1 1/2 cups heavy cream
  • 1/2 cup grated Parmesan cheese
  • 1/2 cup sun-dried tomatoes in olive oil drained and chopped
  • 1 1/2 cups shredded mozzarella cheese
  • 1 tablespoon Italian seasoning blend
  • Fresh ground nutmeg to taste
  • 1 teaspoon pink salt or more to taste
  • 1/2 teaspoon fresh cracked black pepper or more to taste
  • 1 tablespoon butter
  • 1/2 cup keto bread crumbs See Notes
  • 2 teaspoons flat-leaf parsley chopped

Instructions
 

  • Preheat the oven to 350°F (175°C). Lightly grease a 2-quart casserole dish.
  • Cook the pasta according to package instructions. Drain well and return to the pot. Toss the spinach with the hot pasta, cover the pot, and set aside.

Cook the chicken:

  • In a large skillet or Dutch oven, heat 2 tablespoons of olive oil over medium-high heat. Add the chicken and cook until no pink remains, about 5–7 minutes. Transfer the cooked chicken to the pot with the pasta and spinach. Cover to keep warm.

Make the sauce:

  • In a medium saucepan, heat the remaining 2 tablespoons of olive oil over medium heat. Add the garlic and cook for 1 minute, stirring frequently. Sprinkle in the xanthan gum (or flour) and whisk well

Add liquids:

  • Pour in the white wine and heavy cream, stirring constantly. Continue cooking until the sauce thickens, about 5–6 minutes. *See Notes

Season the sauce:

  • Stir in the Italian seasoning, nutmeg, salt, and pepper. Remove the saucepan from the heat and stir in the Parmesan cheese and sun-dried tomatoes.

Combine everything:

  • Add the pasta mixture to the Dutch oven or skillet and stir to combine. Transfer the mixture to the prepared casserole dish.

Toast the bread crumbs:

  • In a small skillet, melt the butter over medium-high heat. Add the bread crumbs and cook, stirring frequently, until browned and toasted, about 3 minutes. Stir in the chopped parsley.

Assemble and bake:

  • Sprinkle the toasted bread crumbs evenly over the pasta. Bake in the preheated oven until the top is golden brown and bubbly, about 20–25 minutes.

Notes

Wine substitution: You can use any dry white wine or vermouth. If you prefer not to use wine, substitute with chicken bone broth.
Bread crumbs: To make keto bread crumbs, toast 2 slices of keto bread until medium-dark, then process into crumbs using a food processor or blender. Regular panko bread crumbs can be used if not low-carb.
Sauce thickness: If the sauce is not thick enough, whisk in an additional 1/2 teaspoon of xanthan gum (or 1 tablespoon of flour) and cook for another 1–2 minutes.

Disclaimer

Most of my recipes are low-carb (or keto) and gluten-free, but some are not. Please verify that a recipe fits your needs before using it. Recommended and linked products are not guaranteed to be gluten-free. Recipes may contain errors, so please use your common sense when following them. Nutritional information is provided as a courtesy and is approximate only. We cannot guarantee the accuracy of the nutritional information given for any recipe on this site. Erythritol carbs will not be included as it has a glycemic index of 0 (meaning it does not spike blood sugar) and it’s not metabolized. Net carbs are the total carbs minus fiber.

Nutrition

Calories: 705kcalCarbohydrates: 63gProtein: 38gFat: 46gSaturated Fat: 22gPolyunsaturated Fat: 3gMonounsaturated Fat: 16gTrans Fat: 0.1gCholesterol: 150mgSodium: 1032mgPotassium: 806mgFiber: 34gSugar: 4gVitamin A: 5769IUVitamin C: 25mgCalcium: 316mgIron: 2mg
Keyword casserole, chicken, comfort food, dinner, easy recipes, freezer friendly, Italian, Keto, kid friendly, Low Carb, main dish, make ahead, pasta
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